Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin
نویسندگان
چکیده
A novel neurotrophic factor named Persephin that is approximately 40% identical to glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) has been identified using degenerate PCR. Persephin, like GDNF and NTN, promotes the survival of ventral midbrain dopaminergic neurons in culture and prevents their degeneration after 6-hydroxydopamine treatment in vivo. Persephin also supports the survival of motor neurons in culture and in vivo after sciatic nerve axotomy and, like GDNF, promotes ureteric bud branching. However, in contrast to GDNF and NTN, persephin does not support any of the peripheral neurons that were examined. Fibroblasts transfected with Ret and one of the coreceptors GFRalpha-1 or GFRalpha-2 do not respond to persephin, suggesting that persephin utilizes additional, or different, receptor components than GDNF and NTN.
منابع مشابه
GFRα-4 and the tyrosine kinase Ret form a functional receptor complex for persephin
Glial-cell-line-derived neurotrophic factor (GDNF) [1], neurturin [2] and persephin [3] are structurally related, secreted proteins that are widely expressed in the nervous system and other tissues [1–5] and promote the survival of a variety of neurons during development [1–12]. GDNF and neurturin signal through multicomponent receptors that consist of the Ret receptor tyrosine kinase and one o...
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ورودعنوان ژورنال:
- Neuron
دوره 20 شماره
صفحات -
تاریخ انتشار 1998